cGP-PRo® is not marketed or sold to consumers. All information contained on this website is provided for scientific research and product development purposes
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is a dipeptide that plays a crucial role in regulating Insulin-like Growth Factor-1 (IGF-1), a hormone essential for growth, development, metabolism, neuroprotection, and cell survival.
IGF-1 performs many biological functions across our lifespan. One of its key functions is maintaining healthy blood circulation. Having robust circulation is vital for healthy functioning of our tissues and organs.
Our IGF-1 levels naturally begin to decline around age 45 or can occur prematurely because of an unhealthy lifestyle, ongoing stressors, and the onset of some health conditions.
Years of extensive research by our Chief Science Officer and scientists globally, have shown the importance of maintaining IGF-1 activity for positive health outcomes as we age.
cGP acts as a key regulator of IGF-1 activity by interacting with its binding proteins. Normally, these proteins bind to IGF-1, making IGF-1 inactive. However, cGP competes for the same binding proteins, freeing IGF-1 and allowing it to become biologically active when needed. Hence, cGP is an important part of maininting health and vitality through its actions on IGF-1.
WHAT IS IGF-1?
IGF-1 (insulin-like growth factor 1) is a hormone that plays an important role in managing and promoting normal growth and development in the human body. Its function as a neurotrophic factor in the brain, makes it essential for brain development and cognitive function.
In addition, IGF-1 also helps with other important processes in the body such as energy metabolism, and wound healing making it a life-essential hormone.
THE PHYSIOLOGICAL IMPACT OF IGF-1
IGF-1 is primarily secreted by the liver and is transported to other tissues, acting as an endocrine hormone. Although it is mainly produced by the liver, several other tissues are also able to secrete IGF-I for autocrine/paracrine purposes; including muscles, bones, and fat cells, where it can act locally to support growth and repair across various stages of life.
IGF-1 function declines with age which can contribute to cardiovascular ageing, declining metabolic health as well as cerebrovascular diseases such as stroke, hypertension, and cognitive impairment.
IGF-1 IN THE DIFFERENT STAGES OF LIFE
IGF-I levels are maximal during peripubertal growth and early adult hood; however, they progressively decline with age. Reduced IGF-I levels in the elderly contribute to age-related symptoms and subsequently, progression of age-related neurological conditions. Maintaining optimal IGF-1 levels and function is important across life-stages especially after the age of 45.
IGF-1: THE BODY'S MASTER REPAIR SIGNAL
IGF 1 is a key molecule that drives growth, repair and renewal throughout the body. But in the bloodstream, it stays inactive unless released from its binding proteins. Once active, IGF 1 binds to receptors on blood vessels and cells, triggering vital repair processes. IGF-1 stimulates cell growth and division, as well as the production of new cells.
It helps grow and regenerate tiny blood vessels called capillaries, delivering oxygen and nutrients while clearing out waste. It also supports cell growth, metabolism and tissue repair — all essential for keeping your body and brain functioning at their best.
As we age, IGF 1 becomes less active. That is where cGP helps. It keeps IGF 1 available and working where your body needs it most.
WHAT IS cGP?
cGP (cyclic-Glycine-Proline) is a molecule that our body produces by itself and is a key player in regulating the IGF-1 activation/inactivation. It works by normalising the IGF-1 function and is crucial for the normal growth of humans, neurological development and improving the brain signalling pathways.
THE IMPORTANCE OF cGP
As we get older, our requirement for cGP increases, while our bodies simply cannot make enough cGP to meet these demands. Thus, pointing to an increased need for cGP supplementation as we age.
BENEFITS OF cGP FOR BRAIN HEALTH AND PROTECTION
cGP helps keep your brain strong by regulating IGF 1, a hormone that plays a central role in growth, repair and overall health. As you age, or when your body is under stress, IGF 1 levels can drop. When that happens, your need for cGP increases.
Without enough cGP, IGF 1 cannot do its job properly. This has been linked to brain conditions like Parkinson’s, Alzheimer’s and dementia.
cGP helps repair and rebuild tiny blood vessels, improving blood flow and nutrient delivery to the brain. This supports better memory, sharper focus, clearer thinking, deeper sleep, more energy and a more balanced mood. Adding cGP to your routine may help support long term cognitive health. It is a powerful step toward protecting your brain and enhancing your quality of life.
BLOOD VESSELS - THE VEINS, THE ARTERIES, AND CAPILLARIES
Blood vessels circulate blood throughout your body delivering oxygen and nutrients to organs and tissues, and they also remove cellular and metabolic waste.
There are three types of blood vessels:
CAPILLARIES
Capillaries are the smallest blood vessels, connecting arteries and veins. They deliver oxygen and nutrients to tissues and remove waste, keeping organs healthy and blood flow clear.
ARTERIES
Carry blood away from your heart
VEINS
Carry blood back towards your heart