cGP-PRo® is not marketed or sold to consumers. All information contained on this website is provided for scientific research and product development purposes

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cGP is short for cyclic Glycine-Proline

An endogenous molecule that plays a key role in making small blood vessels. Around the age of 45, the body’s production of cGP begins to decline. In addition, low levels of cGP correlate with cognitive decline and neurodegenerative diseases.

The hero ingredient in cGP-PRo® is made from specific New Zealand grown blackcurrant cultivars rich in cGP, and collagen. Our proprietary enzymatic process creates a unique ingredient containing high levels of stabilised cGP.

Consuming blackcurrants alone or regular blackcurrant products, is not enough to meet your body’s daily requirement of cGP.

cGP-PRo® is the premium ingredient for brain health. It is scientifically shown to replenish and maintain optimal cGP levels in your brain and body.

How it Works
cGP works by activating IGF-1 (Insulin Like Growth Factor-1). When cGP levels are low, for example in older age, 95% of IGF-1 is bound to a protein that inactivates it. Taking cGP-PRo® restores cGP levels which activates IGF-1.

IGF-1 kickstarts the formation of new blood vessels and regulates nerve cells and DNA synthesis.


IGF-1 (insulin-like growth factor 1) is a hormone that plays an important role in managing and promoting normal growth and development in the human body. Its function as a neurotrophic factor in the brain, makes it essential for brain development and cognitive function.

In addition, IGF-1 also helps with other important processes in the body such as energy metabolism, and wound healing making it a life-essential hormone


IGF-1 is primarily secreted by the liver and is transported to other tissues, acting as an endocrine hormone. Although it is mainly produced by the liver, several other tissues are also able to secrete IGF-I for autocrine/paracrine purposes; including muscles, bones, and fat cells, where it can act locally to support growth and repair across various stages of life. IGF-1 function declines with age which can contribute to cardiovascular ageing as well as cerebrovascular diseases such as stroke, hypertension, and cognitive impairment.


IGF-I levels are maximal during peripubertal growth and early adult hood; however, they progressively decline with age. Reduced IGF-I levels in the elderly contribute to age-related symptoms and subsequently, progression of age-related neurological conditions. Maintaining optimal IGF-1 levels and function is important across life-stages especially after the age of 45.


In the bloodstream, IGF-1 remains bound to ‘binding proteins’ in its inactivated form. In order to be functional, IGF-1 breaks this bond with the ‘binding proteins’ and is activated by its receptors. These receptors are present on cells throughout the body, including bone, muscle, and fat cells, as well as cells in the brain and other organs which allows IGF-1 to execute its function.

IGF-1 helps to produce/re-generate small blood vessels (capillaries) in our body which is crucial as it aids in the transportation of nutrients throughout your body and helps in taking away toxic waste from tissues and organs. IGF-1 stimulates cell growth and division, as well as the production of new cells. It also plays a key role in regulating metabolism, helping to maintain healthy levels of oxygen and other nutrients in the blood. In addition to its role in growth and development, IGF-1 is also involved in the repair and maintenance of tissues throughout the body.


cGP (cyclic-Glycine-Proline) is a molecule that our body produces by itself and is a key player in regulating the IGF-1 activation/inactivation. It works by normalising the IGF-1 function and is crucial for the normal growth of humans, neurological development and improving the brain signalling pathways.


As we get older, our requirement for cGP increases, while our bodies simply cannot make enough cGP to meet these demands. Thus, suggesting an increased need for cGP supplementation as we age.


cGP supports the activity of IGF-1 in the body by normalising the IGF-1 function. Age, stress, and poor lifestyle choices contribute to insufficient IGF-1 and subsequently, increase the demand for cGP. This overwhelms the system as it cannot often meet these demands, making us susceptible to poor health outcomes. Without optimal cGP levels, IGF-1 can no longer operate at its full potential resulting in low/deficient levels of IGF-1 that have been implicated in neurological conditions such as Parkinson’s Disease, Dementia and Alzheimer’s Disease.

cGP helps with the rebuilding and remodelling of small blood vessels and therefore allows to re-establish the connections inside our brain and facilitates the transport of nutrients throughout our body. This can have a positive impact on cognitive function by improving the ability to focus and increasing mental clarity, improving sleep, increased energy levels and a better mood. Increasing cGP levels through supplementation can also help in slowing the progression of neurodegenerative disorders such as Parkinson’s Disease, Alzheimer’s Disease and Dementia thereby supporting overall quality of life.


Blood vessels circulate blood throughout your body delivering nutrients to vital organs and tissues, and also help with taking metabolic waste away. Blood vessels include veins, arteries and capillaries.

There are three types of blood vessels:

The smallest blood vessels, connect arteries and veins and are responsible for facilitating the exchange of  various substances between bloodstream and tissues/organs. This exchange is crucial as it includes delivering nutrients and oxygen to tissues/organs to ensure their health and function and also includes clearing of waste from tissues/organs to avoid the build-up of plaques and obstruction of blood flow.

Carry blood away from your heart

Carry blood back towards your heart

Who Will Benefit Most From cGP-PRo®?

People aged 65+ will experience outstanding benefits from cGP-PRo®, especially those suffering from age-related conditions such as cognitive decline, Dementia, Parkinson’s, or Metabolic Syndrome. cGP-PRo® is also ideal for those over the age of 45 who are starting to notice the first effects of brain ageing.

Benefits of cGP-PRo®

cGP-PRo® is the culmination of 30 years of research on cGP. The function of cGP-PRo® is to encourage the new blood vessels in the brain. Specific health benefits include:

  • Supports memory and cognition in the aging brain. A study showed that older people with higher levels of cGP have better memory and cognition*.

  • Clinically proven to reduce anxiety and depression in Parkinson’s patients*.

  • May support recovery from stroke. A study found that patients with higher cGP levels at the time of their stroke recovered significantly better than those with low cGP levels*.

  • Pre-clinical studies show that restoring cGP helps normalize blood pressure. Human studies show those with metabolic disorders, especially high blood pressure have low levels of cGP*.


World exclusive with two patents filed in over 30 countries

The only natural ingredient to contain a standardised, therapeutic dose of cGP.

Backed by research that spans over 30 years.

Clinically proven to be highly bioavailable.

Proprietary manufacturing process combines enzymatic processing with carefully controlled blending of collagen to concentrate and stabilise cGP.

Made from New Zealand-grown blackcurrants. The country’s pristine environment and strong UV light means that blackcurrants from New Zealand have more natural goodness than blackcurrants from other parts of the world.



Blackcurrant concentrate (Ribes nigrum) and collagen.


Maltodextrin is used as an excipient.
Organic acacia gum is available as an alternative excipient on request.
Also available as a sweetened powder with either non-GMO monk fruit or New Zealand-grown boysenberry powder.


≥400 ng/mg (LC-MSMS)


A free-flowing powder


Fresh, woody, berry


Water soluble


Made in New Zealand


5kg/10kg foil bags


36 months in original packaging


This product complies with the standards as outlined in the Australia & New Zealand Food Standards Code and amendments


cGP-PRo® is supplied as a dry powder. It provides exceptional formulation convenience due to the low daily dose of 100mg (providing ≥40µg cGP). cGP-PRo® can be easily incorporated into hard shell capsules (veg caps or gel caps) or pressed tablets. It also makes a distinctive addition to functional foods and beverages, giving your brand an edge over the competition.

cGP-PRo® can be utilised as a stand-alone ingredient or can be incorporated alongside other active ingredients.

Contact us today to discuss your formulation requirements.

*These statements have not been evaluated by the Food and Drug Administration or any other medicines regulatory agency. This product is not intended to diagnose, treat, cure or prevent any disease. This material is for professional education only. Not suitable for consumer distribution.